Resveratrol is possibly one of the most talked about antioxidant at this time. This recently published study looked at whether Resveratrol improved insulin sensitivity in Type 2 Diabetic patients and also what the possible mechanism of its action is.
19 patients enrolled in this 4-week double blind study. Patients were randomly assigned to receive either 2x5mg Resveratrol or a placebo. After the fourth week, the resveratrol supplemented group had a significantly reduced insulin resistance and reduced oxidative stress. It was concluded that the observed results may be because resveratrol induced a reduction in oxidative stress which lead to efficient activation of insulin signalling via the Akt pathway.
Whilst this small study is the first to attempt to explain the mechanism for resveratrol´s potent antioxidant effect, a larger study will be needed to make definite conclusions. In addition, Nutrigenomic data was not included in this study and it is not clear whether individuals changed their dietary intake or lifestyle during the study apart from the resveratrol-avoiding instructions they were given.
So far, human studies on resveratrol are still lacking but the excitement surrounding this polyphenol is not about to die down. Recent evidence shows that polyphenols seem to have a synergistic effect meaning that it is better to include foods that contain a mixture of polyphenols as found in fruits and vegetables and of course red wine rather than a single ingredient. So if you are still “hyped”, increase the variety of fruit and vegetables in your diet, drink alcohol (red wine) in moderation, have an active lifestyle and maintain a healthy weight.