A research team led by King´s College London and Oxford University have found a master switch gene linked to Diabetes and cholesterol levels that controls the behaviour of other genes which are found in fat cells.This study conducted in twins,was a large multi-national trial funded by the Wellcome trust. By looking at fat biopsies they found that the KLF14 gene was associated with the expression of other genes which are related to metabolic traits such as insulin & glucose levels,a high BMI and cholesterol. The peculiar fact about KLF14 is that its activity is inherited from the mother, inheriting a copy from the father has no effect. This will result in the process of “imprinting” which could impact the offspring.
This exciting study may lead to the development of treatments which could counteract the metabolic effects. So far I have not seen KLF14 in Nutrigenomic panels but this study may change this.