Previous Nutrigenomic studies have linked the -265 T>C on the APOA2 gene with a high BMI and Obesity in the presence of a high saturated fat intake. This Nutrigenomics centre of excellence´s previous work was conducted in three American population groups (Corella et al 2009). This new Nutrigenomic study by Corella et al published in the International Journal of Obesity has extended this work to include individuals of Asian (Chinese, Malay and Singaporean) and Mediterranean ethnic origin. The major finding was when saturated intake was below 22g/day, this SNP did not have any effect on Obesity or BMI. However when saturated fat intake was high (>22g/d), this SNP had a significant impact on anthropometric measurements such as weight and waist circumference in those individuals with the CC genotype (than those with the T-allele). In addition, they found that Chinese and Asian Indians had higher levels of Insulin resistance when saturated intake was high. Quite astonishingly they discovered that out of 3695 Asian individuals included in the study, >55% had Type 2 Diabetes which was undiagnosed. In the Mediterranean population the APOA2 SNP was not associated with Diabetes risk. They concluded that this study contributes to the evidence already found in their previous Nutrigenomic work that highlights a gene-diet interaction. More interestingly, there may be a a new found gene-diet interaction between the APOA2 SNP and saturated fat intake with a risk for Insulin resistance and Diabetes,but further studies are recommended.
The evidence for keeping saturated fat intake low is mounting, however fewer individuals know what 22g of saturated fat looks like in a daily diet. I wonder if the impact of these results on the future of the food industry. Expecting people in a fast-moving, hard working world to go “cold-turkey” on fast foods and processed foods may be too much to ask initially. However would the replacement of saturated fats by monounsaturated oils such as olive oil,be a compromise especially in those who carry the SNP? tell me what you think!
In the mean time, my advice would be to;
- Cook at home, try 1 new dish every two weeks and share it with friends and family
- Pack a healthy lunch
- Fill up on fresh Fruit and Vegetables
- Try a Vegetarian meal at least once per week
- Eat regular meals and know your portion size
- Get Moving!
- If you are overweight and think you may be at risk of Diabetes, contact your physician and get tested
In addition, if you have your Nutrigenomics report and would like further information and personalised advice,please get in touch!
Corella D.,Tai ES.,Sorli JV.,Chew SK.,Coltell O.,Sotos-Prieto M.,Garcia-Rios A., Estruch R., Ordovas JM.Association between the APOA2 promoter polymorphism and body weight in Meditteranean and Asian poplulations: replication of a gene-saturated fat interaction. International Journal of Obesity (2011) 35; 666-675