Adiponectin is a hormone which is secreted by fat cells and regulates glucose and lipid metabolism as well as regulates energy balance. Nutrigenomic studies have established Adiponectin as a protective hormone and ideally you want blood levels to be high to avoid fat deposition and synthesis. This new randomised-controlled Nutrigenomic study just published in the American journal of Clinical Nutrition, looked at the interaction between SNP´s on the ADIPOQ gene,age,BMI,ethnicity,sex,replacement of Saturated fats (from animal products) with Monounsaturated fatty acids (present in walnuts,canola,avocados) or carbohydrates on serum adiponectin concentrations. As mentioned previously Adiponectin is secreted from adipose tissue and high levels have a protective effect.
448 individuals were genotyped and were placed on a high saturated fat diet for 4 weeks followed by a diet which was either low in fat,reference level of fat or high in monounsaturated fats for a 24-week period. The results showed that white G/G Homozygous individuals on a High Monounsaturated diet had increased Adiponectin levels with advancing age.
As mentioned in a previous post, the incidence of Metabolic Syndrome or Syndrome X is increasing globally.Clinical signs and symptoms include: central obesity, insulin resistance, abnormal glucose metabolism, Hypertension and hyperlipidaemia. Evidence suggests that with increased exercise and a Low GI diet, insulin sensitivity can be increased.
If you think you may be at risk, contact your local Physician or if you have had a Nutrigenomics screen which has identified SNP´s which may put you at risk,please contact us for personalised advice
Aseel AlSaleh,Sandra D O’Dell,Gary S Frost,Bruce A Griffin,Julie A Lovegrove,Susan A Jebb,Thomas AB Sanders. Single nucleotide polymorphisms at the ADIPOQ gene locus interact with age and dietary intake of fat to determine serum adiponectin in subjects at risk of the metabolic syndrome. Am J Clin Nutr May 2011 ajcn.014209 doi: 10.3945/ajcn.111.014209